Using the Kemtrak DCP007-NIR to improve chromatographic solvent concentration

Recently, we looked at how the Kemtrak DCP007-NIR can be used to improve chromatographic separations. In this week’s post, we analyse how this popular and diverse instrument can also be used to improve solvent concentration control.

The versatility and efficacy of chromatographic techniques have made them essential in both large scale, and analytical separations.

Chromatography is widely used in bio-processing to separate protein molecules from concentrated process fluids.

The centre of a chromatography system is the column, filled with a media specific to the separation to be carried out.

How is the technique applied?

Solvent gradient control can significantly enhance peak separation and the process economy of chromatography applications.

An in-line quantitative sensor permits on-line mobile phase assessment, which with controlled feedback can guarantee accurate and reproducible results.

Controlled gradients minimize the effects of changing properties of the stock solvents.

How was the instrument installed?

Pre-Column chromatography monitoring:

The Kemtrak DCP007-NIR mounted in-line before the chromatography column, continuously monitoring the solvent concentration, gives the user control over the composition delivered to the chromatography column.

The online monitoring of solvent composition is more significant than measuring physical parameters like mass flow alone. As It allows the generation of batch reports that confirm the actual gradient composition and inhibits the incorrect use of a solvent.

The Kemtrak hygienic measurement cells available with FDA and UPC VI approved materials, convenient zero dead volume design; contain no electronics or moving parts for ease of use.

There are two versions of the Kemtrak DCP007-NIR currently available:

DCP007-NIRL (850 – 1550 nm) for measurement of 0 - 100% water and solvent gradients.
DCP007-NIRH (850 – 2000 nm) for trace water and hydrocarbon detection. This model incorporates a multiple stage Peltier cooled and temperature regulated photodiodes and NIR LED light source for the very best in stability and performance.

For more information about this instrument and how it can help you with your chromatographic processes, please call us on: 01442 87677 or email: [email protected], where we will also be happy to provide you with a free, no obligation quote.
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