At Fullbrook Systems, one of our most popular product ranges is the Turbiscan by Formulaction. Over the years, these instruments have been cited in hundreds of journals and peer-reviewed articles across biology, chemistry, pharmaceuticals, and engineering.
This week, we focus on how the Turbiscan can help optimise vaccine efficiency via separation and flocculation testing.
What are the benefits of using the Turbiscan for this purpose?
Firstly, the Turbiscan provides fast and reliable migration rates. This means you can rapidly quantify particle migration rates to characterise vaccine stability and dose uniformity.
You can also study the ability of the drug to redisperse under storage time or temperature conditions, and work on the sample without the need of dilution.
This allows the testing of prefilled syringes or vials. All types of vaccines can be worked on with the Turbiscan, including deactivated, attenuated virus, m-RNA and toxoids.
How will the Turbiscan help me with the development process?
To shorten the development process, scientists need reliable characterization methods to rapidly optimize formulations with inactivated-attenuated viruses or next generation vaccines (DNA, mRNA, etc.).
Vaccine efficiency depends highly on the dispersion state of the product at the moment of administration, which is why vaccines often need to be reconstituted before they can be used.
Physical characterization of vaccines can be achieved by measuring the migration and flocculation rates and thus evaluate the dispersion state over time.
Analysis with the Turbiscan is reliable and highly precise, enabling the optimization of the vaccine formulation. This optimisation gives enhanced dose uniformity, optimised efficiency and easy reconstitution.
How does the Turbiscan technology work?
The Turbiscan uses Static Multiple Light Scattering (SMLS) to detect particle migration and size variation in liquid dispersions. The Transmission (T) and Backscattering (BS) signals measured are related to particle size, and concentration, and their variation over time is a sign of destabilization.
The Turbiscan® range has been used worldwide for over 25 years, to detect at an early stage all kinds of destabilizations such as coalescence, flocculation, creaming, and sedimentation.
As mentioned earlier, any samples including emulsions, suspensions, dispersions, or foams can be studied at full concentration range (up to 95 %v/v) without dilution or sample preparation.
Are there any other features of the Turbiscan that can help me with my vaccine development?
Scientists need to consider biological, chemical, and physical challenges at each step of the process, as well as all related conditions, to maintain the product’s long shelf life. As well as the benefits outlined above, the Turbiscan can also help with:
• Faster vaccine characterisation – a 24-hour visual observation can be undertaken in 30 minutes due to highly sensitive detection systems.
• Boost vaccine immunogenicity through adjuvant selection and formulation adjustment.
• Quickly screen a large panel of vaccine carrier molecules
• Easily reconstitute and resuspend formulations for perfect dosing.
• User friendly equipment - quick and easy to deploy and operate.
• Create products with a long shelf life by studying your formulations under real storage conditions.
How do I find out more about the Turbiscan and its vaccine stability applications?
Please call us on 01442 876777 or email firstname.lastname@example.org for a no obligation quote, or to discuss your requirements further.
October 2016 Fullbrook Systems Ltd move to new premises in Hemel Hempstead. After being in the same offices for many years the company moved to more suitable premises