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Vaccine stability
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Turbiscan Tlab
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Vaccine re-dispersability measurent
Vaccines are a well recognised and crucial part of a national health strategy. Often containing many ingredients the ability to rapidly determine the stability of the formulation is absolutely essential.
A common cause of instability is the use of adjuvants, in particular, aluminium salts. These not only help promote the immune response but can contribute to the vaccine's stability. Over time these adjuvants can aggregate due to their electrical charges, and this can lead to settling / sedimentation over time. The resultant sediment layer can be more or less redispersible depending on the strength of interactions between the particles. This can affect the efficient redispersibility of the vaccine prior to injection.
If sedimentation / aggregation occurs, it is important to confirm -
(a) .... The injected dose always remains the same. (Concentration affected by sedimentation)
(b) .... The therapeutic efficacy is always the same. (Masking of the antigen by aggregation)
Traditionally the standard test methods are time consuming for example the SVR (Sedimentation Volume Ratio) is determined over a period of 24 Hours. However the Turbiscan® can be used to determine the Sonset (Settling Onset Time). This rapid test method can predict the type of sediment produced.
Sonset > 60 min - Hard sediment layer, difficult to redisperse
Sonset < 30 min - Soft sediment layer, easy to redisperse
By using the Turbiscan® it is possible to measure / control the type of sediment layer generated and ensure the correct immunogenicity of the vaccine.
A common cause of instability is the use of adjuvants, in particular, aluminium salts. These not only help promote the immune response but can contribute to the vaccine's stability. Over time these adjuvants can aggregate due to their electrical charges, and this can lead to settling / sedimentation over time. The resultant sediment layer can be more or less redispersible depending on the strength of interactions between the particles. This can affect the efficient redispersibility of the vaccine prior to injection.
If sedimentation / aggregation occurs, it is important to confirm -
(a) .... The injected dose always remains the same. (Concentration affected by sedimentation)
(b) .... The therapeutic efficacy is always the same. (Masking of the antigen by aggregation)
Traditionally the standard test methods are time consuming for example the SVR (Sedimentation Volume Ratio) is determined over a period of 24 Hours. However the Turbiscan® can be used to determine the Sonset (Settling Onset Time). This rapid test method can predict the type of sediment produced.
Sonset > 60 min - Hard sediment layer, difficult to redisperse
Sonset < 30 min - Soft sediment layer, easy to redisperse
By using the Turbiscan® it is possible to measure / control the type of sediment layer generated and ensure the correct immunogenicity of the vaccine.
| vaccine_stability_ts_stab_54_.pdf |
There is noting like letting our chemists test your own samples to find out what a Turbiscan is capable of and how it can really help you to speed up formulation development, assess shelf life or make quality control measurements.
Contact us at Fullbrook Systems & ask us to test some samples - there is no cost or obligation
Tel 01442 876 777
Email sales@fullbrook.com
In addition we have a wide range of application notes from across industry.
Contact us at Fullbrook Systems & ask us to test some samples - there is no cost or obligation
Tel 01442 876 777
Email sales@fullbrook.com
In addition we have a wide range of application notes from across industry.
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How does a turbiscan work |
Test anything from ink to cosmetics to pharmaceuticals
Emulsions - Suspensions - Foams |
what can a turbiscan detect> MIGRATION ANALYSIS
Local variation of light intensity corresponds to phases formation.
> TURBISCAN STABILITY INDEX
Turbiscan Stability Index is a one-click parameter to easily rank the stability of many samples in a kinetic way or in a data table. The higher the TSI is, the less stable the product is. |
> SIZE VARIATION ANALYSIS
Global variation of light intensity corresponds to size increase.
> NO MECHANICAL STRESS
When it comes to shelf-life, and real-life evolution of the end-products, it makes no sense to apply a mechanical stress to a sample. Our measurements are always performed at rest, without any external stress. That way, you can be sure that the results you get are representative of what will happen in real life, only detected way earlier! |