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HOME                TURBISCAN          RHEOLASER      FLUIDICAM      APPLICATIONS         MEASUREMENT CELLS  

Turbiscan Applications: Vaccine Stability

 TLAB                TOWER                TAGS            CLASSIC 2             OIL SERIES           APPLICATIONS         MEASUREMENT CELLS  
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Vaccine re-dispersability measurent

Vaccines are a well recognised and crucial part of a national health strategy. Often containing many ingredients the ability to rapidly determine the stability of the formulation is absolutely essential.

A  common cause of instability is the use of adjuvants, in particular, aluminium salts. These not only help promote the immune response but can contribute to the vaccine's stability. Over time these adjuvants can aggregate due to their electrical charges, and this can lead to settling / sedimentation over time. The resultant sediment layer can be more or less redispersible depending on the strength of interactions between the particles. This can affect the efficient redispersibility of the vaccine prior to injection.

If sedimentation / aggregation occurs, it is important to confirm:
(a) The injected dose always remains the same (concentration affected by sedimentation).
(b) The therapeutic efficacy is always the same. (Masking of the antigen by aggregation)

Traditionally the standard test methods are time consuming for example  the SVR (Sedimentation Volume Ratio) is determined over a period of 24 Hours. However the Turbiscan® can be used to determine the Sonset (Settling Onset Time). This rapid test method can predict the type of sediment produced.

Sonset > 60 min  - Hard sediment layer, difficult to redisperse
Sonset < 30 min - Soft sediment layer, easy to redisperse

By using the Turbiscan® it is possible to measure and control the type of sediment layer generated and ensure the correct immunogenicity of the vaccine.
vaccine_stability_ts_stab_54_.pdf
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There is noting like letting our chemists test your own samples to find out what a Turbiscan is capable of and how it can really help you to speed up formulation development, assess shelf life or make quality control measurements.   

Contact us at Fullbrook Systems to test some samples:

Tel: 01442 876 777                                                                                                                                                         
​Email: sales@fullbrook.com

In addition we have a wide range of application notes from across industry.   

How does a Turbiscan work?

  • Sample scanned at user defined timed intervals
  • Whole sample scanned bottom to top
  • No sample dilution
  • Readings taken every 20µm
  • Simple stability index / rating
  • Detailed stability data as required
  • Results 40 times quicker than the naked eye
Test anything from ink to cosmetics to pharmaceuticals, as well as emulsions, suspensions and foams.

What can a Turbiscan detect?

Migration Analysis

Local variation of light intensity corresponds to phases formation.

  • Phase thickness kinetics
  • Sedimentation rate
  • Creaming rate
  • Particles migration speed
  • Hydrodynamic diameter.
Turbiscan Stability Index

Turbiscan Stability Index is a one-click parameter to easily rank the stability of many samples in a kinetic way or in a data table. 
The higher the TSI is, the less stable the product is.

Discover More
Size Variation Analysis

Global variation of light intensity corresponds to size increase.

  • Size kinetics 
  • Mean diameter 
  • Agglomeration rate
  • Coalescence rate
  • Dispersibility ratio.


​
No Mechanical Stress

When it comes to shelf-life, and real-life evolution of the end-products, it makes no sense to apply a mechanical stress to a sample.

Our measurements are always performed at rest, without any external stress.

That way, you can be sure that the results you get are representative of what will happen in real life, only detected way earlier!

Fullbrook Systems

Tel  +44 (0) 1442 876 777
Email sales@fullbrook.com

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  • Home
  • Products
    • Formulaction Turbiscan >
      • Turbiscan >
        • Turbiscan Lab
        • Turbiscan Tri Lab
        • Turbiscan Tower
        • Turbiscan AGS
        • Turbiscan Classic 2
        • Turbiscan Oil Series
        • Turbiscan Stability Index
        • Turbiscan Measurement Cells
      • Curing Analyser
      • Fluidicam
      • Turbiscan Rheolaser >
        • Turbiscan Rheolaser Crystal
      • Turbiscan Applications >
        • Turbiscan Industry Applications >
          • Vaccine Stability
    • DISPERMAT Dispersion >
      • Production Machines
      • DISPERMAT Dissolvers >
        • Laboratory Dissolvers >
          • Explosion proof dissolvers
        • Vacuum Mixer Dissolvers
      • Basket Mills >
        • Laboratory Basket Mills
      • Bead Mills >
        • DISPERMAT APS Vertical Bead Mill
      • Industrial Stirrers
      • Rotor Stator
      • Accessories >
        • Impellers & Milling Disks
        • DISPERMAT Accessories
        • Milling Beads
        • Dispersion Process
    • Kemtrak Analysers >
      • Kemtrak Inline Turbidity Meter
      • Kemtrak Photometer - Colour & Concentration Measurement
      • Kemtrak Backscatter Probe
      • Kemtrak Oil In Water Probe
      • Inline Flow Cells & Flanges
      • Kemtrak Accessories
      • Applications >
        • Water & Waste
    • Wilhelm NIemann Dissolvers >
      • Kreis Trial Facility
      • Kreis Dissolvers >
        • Kreis Dissolvers
        • Top Mounted Kreis Dissolver
        • Butterfly Twin Shaft Dissolver Mixer
        • ADVTS Triple Shaft Dissolver Mixer
      • Kreis Basket Mills >
        • Kreis Basket Mill Flat Cover
        • Kreis Basket Mill - Vacuum Cover
        • Kreis Basket Mills for Laboratory & Pilot Plants
    • Inline Refractometers >
      • Inline Refractometer
      • Eythylene Glycol Sensor
    • Brookfield Viscometers >
      • Process Viscometers >
        • AST100 Process Viscometer
        • TT100 Process Viscometer
        • VTE250 Process Viscometer
        • BF35 & PVS Viscometers
      • Fulcan Solvent Dispensers
      • Laboratory Viscometers - Brookfield Ametek >
        • Rheometers
        • Texture Analysers
      • Applications >
        • Can Coating
        • Food Viscosity
    • Powerwise Ink Pumps
  • News
    • Exhibitions
    • Webinars
  • Contact
  • FAQs